KSM-66

What is the difference between KSM-66 and Shoden?

Both are standardised Withania somnifera extracts but with different specifications. KSM-66 is a root-only extract standardised to ≥5% withanolides, with the largest body of clinical evidence. Shoden is a leaf-and-root extract standardised to ≥35% withanolide glycosides — a much higher concentration enabling lower per-dose amounts (120 mg vs 600 mg) with primary evidence in cortisol attenuation and sleep. Both are clinically valid; choice depends on dose preference and which evidence base matters most.

When should I take it — morning or evening?

Either works. Morning dosing supports diurnal cortisol rhythm management for daily stress; evening dosing is appropriate when sleep quality is the primary goal. Consistency is what matters — pick a time you will keep daily.

Is KSM-66 safe to take long-term?

Yes. KSM-66 has documented safety in 8-week and 12-week RCTs, and traditional ashwagandha use in Ayurveda extends across decades. Discuss long-term use with your physician if you have thyroid, autoimmune, or hormone-sensitive conditions.

Can men and women both use it?

Yes. The cortisol attenuation, sleep, and cognitive benefits apply across both sexes. Testosterone-supporting effects in Wankhede 2015 were measured in men; women should not expect testosterone elevation but do receive the broader adaptogenic benefits.