Calm

Stress is a feeling of emotional or physical tension. It can
come from any event or thought that makes you feel frustrated, angry, or
nervous. Stress is your body’s reaction to a challenge or demand. Your body
reacts to stress by releasing hormones such as cortisol (stress hormone).
Chronic stress has been associated with a number of illnesses, including
obesity. The exacerbation of negative mood in response to external stress
elements is highly correlated with increased food intake, and chronic stress is
also associated with reduced physical activity. Both these behaviors may have a
significant impact on body weight. 

Your body reacts to stress by releasing hormones. These
hormones make your brain more alert, cause your muscles to tense, and increase
your pulse. In the short term, these reactions are good but when you have
chronic stress, over time, this puts you at risk for health problems, including
high blood pressure, heart disease, diabetes, obesity, depression or anxiety,
skin problems, such as acne or eczema, menstrual problems, hair loss, etc. 

In today’s world every healthy adult whether a student or a
working professional, managing a business, home or kids, should consider
Unived’s De-Stress to save oneself from chronic stress and its harmful effects
on it. 

Our Formulation

Unived’s CALM is made of KSM-66® Ashwagandha Root Extract
600mg (Organic Vegan Ashwagandha) standardized to 5% Withanolides, Green Tea
Extract standardized to L-Theanine 200mg, and 5-Hydroxytryptophan 50mg from
Griffonia Extract.

Mode of Action:

KSM-66® Ashwagandha: KSM-66® is an adaptogenic herb from the
roots of Ashwagandha (Withania somnifera) that has the most extensive set of
research studies and clinical trials.

• KSM-66® Ashwagandha significantly decreased the levels of
  serum cortisol by 22.2% [3], [4].
• Ashwagandha mimics GABA and reduces the over-excitation of
  neurons, thereby producing calmness, reducing stress, and increasing focus,
  mental well-being, and self-control [3], [4].
• Can be helpful in limiting stress-associated weight gain in
  humans [3], [4].

L-Theanine: L-Theanine is a polyphenol extract from Green
Tea (Camellia sinensis) plant. It is known for its therapeutic values.

• Has modulatory effects on the brain state [5].
• It has been shown to regulate the oscillatory brain
  activities in humans with an ability to pass through the blood-brain barrier
  during cognitive task execution and is believed to cause a relaxation effect
  [5].
• Theanine modulates several parameters of brain functions,
  including an increase in GABA, dopamine, and serotonin production [10].
• It may reduce heart rate and other physiological stress
  reactions in a stressful situation [11].
• Neuroprotective and cognition-enhancing agent [6].
• Increases serotonin production [7].
• Induces alpha-brain wave activity, a sign of induced
  relaxation [7].

5-Hydroxy Tryptophan (5-HTP): 5-HTP is the intermediate
metabolite of the amino acid L-tryptophan in the serotonin pathway.

• Increases serotonin uptake [9].

References:

1. Choudhary, Bakhtiar, A. Shetty, and Deepak G. Langade.
"Efficacy of Ashwagandha (Withania somnifera [L.] Dunal) in improving
cardiorespiratory endurance in healthy athletic adults." Ayu 36.1 (2015):
63.

2. ‘Ingredient Overview: highly bioavailable, clinically
effective, sustainably produced.’ www.ashwagandhaadvantage.com

3. ‘KSM-66® Ashwagandha/scientific studies: highly
bioavailable, clinically effective, sustainably produced.’
www.ashwagandhaadvantage.com

4. Choudhary, Dnyanraj, Sauvik Bhattacharyya, and Kedar
Joshi. "Body weight management in adults under chronic stress through
treatment with ashwagandha root extract: a double-blind, randomized,
placebo-controlled trial." Journal of evidence-based complementary &
alternative medicine 22.1 (2017): 96-106.

5. Higashiyama, Akiko, et al. "Effects of l-theanine on
attention and reaction time response." Journal of Functional Foods 3.3
(2011): 171-178.

6. Hidese, Shinsuke, et al. "Effects of L-theanine
administration on stress-related symptoms and cognitive functions in healthy
adults: a randomized controlled trial." Nutrients 11.10 (2019): 2362.

7. “Monograph: L-Theanine”, Alternative Medicine Revie.
Volume 10, Number 2, 2005.

8. “Monograph: 5-Hydroxytryptophan”, Alternative Medicine
Review Monographs Copyright© 2002 Thorne Research, Inc. All rights reserved.
Alternative Medicine Review Monographs

9. Tafet, Gustavo E., et al. "Correlation between
cortisol level and serotonin uptake in patients with chronic stress and
depression." Cognitive, Affective, & Behavioral Neuroscience 1.4
(2001): 388-393.

10. Nathan, Pradeep J., et al. "The neuropharmacology
of L-theanine (N-ethyl-L-glutamine) a possible neuroprotective and cognitive
enhancing agent." Journal of Herbal Pharmacotherapy 6.2 (2006): 21-30.

11. Song, Chan Hee, et al. "The Effects of L-theanine
Containing Functional Beverage on Mental Relaxation and Fatigue
Perception." Journal of the Korean Academy of Family Medicine 23.5 (2002):
637-645.