D3+K2-7

The combination of vitamin D3 and K2 has gained attention
recently due to their complementary effects. There has been an increase in
promising research on the synergistic effect of combining these two vitamins in
everyday supplements [1].

Vitamins D3 and K2 are both fat-soluble vitamins and play a
central role in calcium metabolism. Vitamin D3 helps in the effective
absorption of calcium and Vitamin K2-7 directs the absorbed calcium to bones.
Without Vitamin D3, calcium will be excreted via the kidney and without Vitamin
K2-7, calcium won’t be deposited in the bones.

When there is vitamin D3 without enough vitamin K, the
calcium might not transfer to the bones properly and instead end up in the
vascular tissue or arteries. This is because vitamin K is required to activate
proteins that concentrate calcium in bones, such as matrix GLA and osteocalcin.
Vitamin D3 promotes the production of vitamin K-dependent proteins, which
require vitamin K for carboxylation in order to function properly [1]. Thus,
the co-supplementation of D3 with vitamin K2 may minimize this calcification
risk and better calcium utilization as they both complement each other.

Our Formulation

Unived D3+K2-7 is formulated with 600 I.U. of Vitamin D3
sourced from lichen, a plant-based source of Vitamin D3, and 33.34mcg Vitamin
K2-7 as Menaquinone-7 from fermented chickpeas. There is also 79.1mg of Medium
Chain Triglycerides (MCT) to facilitate the transport and absorption of other
vitamins.

Mode of Action:

• Genetic, molecular, cellular, and human evidence support
  that optimal concentrations of both vitamin D and vitamin K are beneficial for
  bone and cardiovascular health. Vitamin K is needed for the carboxylation of
  vitamin K-dependent proteins such as osteocalcin and matrix Gla protein, while
  vitamin D promotes the production of vitamin K-dependent protein
  concentrations. These vitamin K-dependent proteins are needed for the bone and
  the vascular system. This will result in bone mineralization and will inhibit
  soft tissue calcification, which will ultimately lead to lower risks of
  fractures and coronary heart disease [1].
• Vitamin D3 also modulates innate and adaptive immune
  responses thereby promoting immune health.

References:

1. van Ballegooijen AJ, Pilz S, Tomaschitz A, Grübler MR,
Verheyen N. The Synergistic Interplay between Vitamins D and K for Bone and
Cardiovascular Health: A Narrative Review. Int J Endocrinol. 2017;2017:7454376.
doi: 10.1155/2017/7454376. Epub 2017 Sep 12. PMID: 29138634; PMCID: PMC5613455.