The liver is an important organ that can completely
regenerate and even grow even after being damaged and has a key role in the
maintenance of homeostasis and is mainly responsible for the detoxification
process. Apart from detoxification, the liver is responsible for multiple
metabolic functions and physiological processes such as bile production, energy
generation, vitamin storage, and the metabolism of carbohydrates, proteins, and
lipids [1].
The blood after intestinal absorption is transported to the
liver via the portal vein, which not only carries nutrients but also multiple
toxic substances including alcohol, drugs, pharmaceuticals, and toxins to the
liver. As a result, the liver is susceptible to toxicity and damage [1]. The
detoxification process of the liver is highly efficient, but during the
process, the liver generates free radicals, which damage the liver over the
long –term.
Several factors can inhibit liver function, including a diet
high in trans-fat and preservatives, exposure to environmental toxins, and
consuming too much alcohol. A stressed liver can cause problems with digestion,
detoxification, and even difficulty losing weight. Our Liver Health is
formulated for daily liver protection along with long-term liver health.
Our Formulation
Unived Liver Health synergistic formulation of Milk Thistle,
Curcumin, Black Pepper extracts, and Ginger root powder provides daily liver
health and digestion support.
Mode of Action:
Liver protection repair:
- Milk Thistle has both hepatoprotective and regenerative
actions. It helps in the reduction of the free radicals formed by toxins that
damage the cell membranes [1] - Prevents the activation of the inflammasomes, and NF-kB,
which are important in regulating the immune response in inflammatory states
[3]. - May augment the generation of glutathione in the liver via
an increase in substrate availability (i.e. cysteine) for its biosynthesis,
which subsequently contributes to the enhancement of its antioxidant capacity
in liver tissues [4]
Antioxidant action:
- Curcumin is very well known for its anti-inflammatory and
antioxidant properties. - Curcumin exerts its anti-oxidant actions by protecting the
liver from Carbon Tetrachloride (CCl4 is one of the causes of liver damage,
developing fibrosis, and further cirrhosis. CCl4 initiates cell damage by
producing free radicals and increasing collagen synthesis through the lipid
peroxidation mechanism) induced liver injury by reducing oxidative stress,
inhibiting lipid peroxidation, and increasing glutathione peroxidase activation
[2].
Anti-inflammatory and Digestive Action:
- Ginger powder is well known for its digestive aids and GI
tract protection. - Promote the elimination of intestinal gas to prevent
bloating and flatulence. - Has intestinal spasmolytic properties which relax the
gastrointestinal muscles to soothe an upset stomach. - Ginger inhibits inflammatory markers.
References:
1. Vargas-Mendoza N et al. Hepatoprotective effect of
silymarin
2. Lee HY, Kim SW, Lee GH, Choi MK, Jung HW, Kim YJ, Kwon
HJ, Chae HJ. Turmeric extract and its active compound, curcumin, protect
against chronic CCl4-induced liver damage by enhancing antioxidation. BMC
Complement Altern Med. 2016 Aug 26;16(1):316. doi: 10.1186/s12906-016-1307-6.
PMID: 27561811; PMCID: PMC5000414.
3. Tighe, Sean P., et al. "Chronic liver disease and
silymarin: A biochemical and clinical review." Journal of Clinical and
Translational Hepatology 8.4 (2020): 454.
4. Gillessen, Anton, and Hartmut H-J. Schmidt.
"Silymarin as supportive treatment in liver diseases: A narrative
review." Advances in therapy 37.4 (2020): 1279-1301.
