Women
Women are more likely to suffer from joint pain and
inflammation as a result of arthritis, osteoarthritis, and rheumatoid arthritis
[2]. The risk of arthritis in women increases significantly post-menopause [3].
Owing to curcumin’s potent anti-inflammatory function, CurQ10 can relieve joint
pain in women arising from arthritis, osteoarthritis, and rheumatoid arthritis.
CurQ10 may also protect women from inflammation specific to the menstrual
cycle, like lower back pain.
Athletes
As CoQ10 is extensively involved in energy production, it is
of particular interest to athletes and physically active individuals. CoQ10 is
known to increase aerobic capacity and endurance, reduce oxidative stress, and
improve muscle performance [4]. Regular consumption of CurQ10 may result in
superior aerobic performance and faster muscle recovery in athletes and active
individuals [5]. CurQ10 can help athletes combat the repetitive stress on their
muscles and other connective tissue, and fortifies bones and joints against
potential damage due to intensive training.
Elderly
CoQ10 levels in the body deplete with age, particularly past
the age of 40. Rapid depletion of CoQ10 can lead to cellular damage and death,
and the slowing down of energy production in the body. CurQ10 helps maintain
healthy CoQ10 levels in elderly individuals, thus helping to restore energy
levels, counter cellular damage, and maintain immune function. [6] Both CoQ10
and curcumin have also shown promise in delaying the onset of neurodegenerative
disorders like dementia and Parkinson’s disease, and cognitive decline. [7]
Vegans
CoQ10 is found in limited food sources, which are largely
non-vegetarian like pork and beef. Moreover, dietary sources of CoQ10 would
have to be consumed in large quantities. Vegan sources of CoQ10 are even more
limited, thus making supplementation essential for vegans to maintain healthy
levels of CoQ10. CurQ10 is a 100% vegan/vegetarian supplementation that
contains no animal ingredients and is a safe and ethical way to meet one’s
recommended dietary intake of CoQ10.
Our Formulation
CurQ10 is a 100% natural supplement formulated from 306mg
fermented Coenzyme Q10, 10mg Piperine, and 100mg standardized phytochemical
extracts of Curcumin. CurQ10 offers wide-ranging anti-inflammatory,
antioxidant, heart protection, and anti-aging.
Mode of Action:
1. Anti-inflammatory action:
a. Curcumin:
- Studies have demonstrated that Curcumin switches off
inflammation at the molecular level by blocking cyclooxygenase-2 (COX-2), an
enzyme that makes prostaglandins that are mainly involved in inflammation. [8] - Curcumin also promoted the synthesis of Cortisol, a hormone
that naturally reduces inflammation, and flushes out inflammation-causing
toxins out of joints [8]. - Curcumin has been demonstrated to be particularly effective
against inflammation arising from Osteoarthritis and Rheumatoid arthritis,
tendinitis, ulcerative colitis, and irritable bowel syndrome [9].
b. CoQ10:
- CoQ10 has shown promising results in reducing inflammation,
especially in patients recovering from heart treatments. - CoQ10 lowers levels of interleukin-6 and C-reactive protein,
which are markers for cardiac-related inflammation. [10] - CoQ10 supplementation can significantly reduce inflammation
in individuals suffering from coronary artery disease. [10]
2. Antioxidant action:
a. Curcumin:
- Curcumin combats free-radical damage of cells associated
with conditions like atherosclerosis and neurodegenerative disorders. [7] - Curcumin’s role as an antioxidant goes hand-in-hand with its
anti-inflammatory action. As an antioxidant, curcumin aids in the prevention of
tissue damage and boosts immune function.
b. CoQ10:
- CoQ10 can easily donate electrons to other cells in the body
and neutralize free radicals, thus protecting cellular components like lipids,
DNA, and protein against free-radical damage. [11] - The antioxidant mechanism of CoQ10 has also been
demonstrated to be highly effective against heart disease [10], immune
disorders [4], and periodontal disease [12].
3. Heart protective action:
a. Curcumin:
- Curcumin can prevent the accumulation of oxidized
cholesterol in the body, thereby lowering the risk of heart attacks and strokes
[13]. - Curcumin’s cardiac protection also extends to heart disease
associated with atherosclerosis and diabetes. - Studies have demonstrated the cholesterol-lowering function
of Curcumin. Curcumin signals proteins in the liver to actively flush LDL out
of the body-thus, lowering harmful LDL levels in the body [13].
b. CoQ10:
- As an antioxidant and anti-inflammatory, CoQ10 has also been
shown to reduce markers associated with cardiac stress and myocardial
infarction [10]. - CoQ10 keeps cardiac conditions such as arteriosclerosis,
cardiomyopathy, arrhythmia, and hypertension at bay [14].
4. Anti-aging action:
a. Curcumin:
- Curcumin slows down signs of mental aging and lowers the
risk of brain degeneration, cognitive decline, and neurodegenerative disorders
[7]. - Curcumin reduces signs associated with physiological aging
such as arterial stiffness and oxidative stress [15]. - Curcumin boosts the production of collagen, a protein that
maintains the elasticity and firmness of the skin [16].
b. CoQ10:
- CoQ10 reverses mitochondrial damage, which can potentially
slow down the aging process. - CoQ10 is also shown to directly impact the expression of
genes that control the aging process, thus controlling the aging process at a
genetic level [17].
References:
1. Aggarwal, Bharat B., Young-Joon Surh, and Shishir
Shishodia, eds. The molecular targets and therapeutic uses of curcumin in
health and disease. Vol. 595. Springer Science & Business Media, 2007.
2. Callahan, Leigh F., Jaya Rao, and Michele Boutaugh.
"Arthritis and women’s health: prevalence, impact, and prevention."
American journal of preventive medicine 12.5 (1996): 401-409.
3. Aging Changes in the Bones-Muscles-Joints, Medline Plus,
US National Library of Medicine, NIH.
4. Gaby, Alan R. "The role of coenzyme Q10 in clinical
medicine: Part I." Alt Med Rev 1.1 (1996): 11-17.
5. Kon, Michihiro, et al. "Reducing exercise-induced
muscular injury in kendo athletes with supplementation of coenzyme Q10."
British journal of nutrition 100.4 (2008): 903-909.
6. Bliznakov, Emile G. "Coenzyme Q10, lipid-lowering
drugs (statins) and cholesterol: a present day Pandora’s box." J Amer
Nutraceutical Assoc 5.3 (2002).
7. Cox, Katherine HM, Andrew Pipingas, and Andrew B.
Scholey. "Investigation of the effects of solid lipid curcumin on
cognition and mood in a healthy older population." Journal of
psychopharmacology 29.5 (2015): 642-651.
8. Akram, Muhammad, et al. "Curcuma longa and curcumin:
a review article." Rom J Biol Plant Biol 55.2 (2010): 65-70.
9. Menon, Venugopal P., and Adluri Ram Sudheer.
"Antioxidant and anti-inflammatory properties of curcumin." The
molecular targets and therapeutic uses of curcumin in health and disease
(2007): 105-125.
10. Lee, Bor-Jen, et al. "Effects of coenzyme Q10
supplementation on inflammatory markers (high-sensitivity C-reactive protein,
interleukin-6, and homocysteine) in patients with coronary artery
disease." Nutrition 28.7-8 (2012): 767-772.
11. Dighe, Nachiket S., et al. "COQ10 A wonder enzyme:
A review." Pharma Chem 1.2 (2010): 236-250.
12. Prakash, Shobha, J. Sunitha, and Mayank Hans. "Role
of coenzyme Q10 as an antioxidant and bioenergizer in periodontal
diseases." Indian journal of pharmacology 42.6 (2010): 334.
13. Alwi, Idrus, et al. "The effect of curcumin on
lipid level in patients with acute coronary syndrome." Acta Med Indones
40.4 (2008): 201-210.
14. Kumar, Adarsh, et al. "Role of coenzyme Q10 (CoQ10)
in cardiac disease, hypertension and Meniere-like syndrome." Pharmacology
& therapeutics 124.3 (2009): 259-268.
15. Sikora, E., et al. "The promise of slow down ageing
may come from curcumin." Current pharmaceutical design 16.7 (2010):
884-892.
16. Panchatcharam, Manikandan, et al. "Curcumin
improves wound healing by modulating collagen and decreasing reactive oxygen
species." Molecular and cellular biochemistry 290.1 (2006): 87-96.
17. Lina Buchanan, CoQ10: The Longevity Factor
hht://www.lef.org/Magazine/2013/1/CoQ10-The-Longevity-Factor/Page-01?checked=1
