What is N-acetyl-l-cysteine (NAC)?
N-acetyl-L-cysteine (NAC) is a versatile compound with
numerous applications. As a precursor to the amino acid L-cysteine, NAC
functions as an antioxidant. The primary role of NAC as an antioxidant stems
from its ability to increase intracellular glutathione concentrations.
Glutathione is often referred to as the body's master endogenous antioxidant,
as it is present in every cell and helps combat oxidative stress linked to
various chronic health conditions. However, NAC's benefits extend beyond its
antioxidant properties. This multifaceted molecule exerts positive effects
through additional mechanisms, highlighting its broad utility and potent
protective capabilities. These factors make NAC one of the most promising
antioxidant supplements. Additionally, as a drug, NAC has wide-ranging
applications due to its therapeutic potential.
NAC as an Antioxidant and Anti-Inflammatory for
Respiratory, Immune and Skin Health
N-acetyl-L-cysteine (NAC) supplies cells with the necessary
building blocks to naturally produce glutathione, a potent antioxidant. Apart
from its role in glutathione synthesis, NAC directly acts as an antioxidant by
neutralizing free radicals before transforming into glutathione, potentially
averting cellular damage. Moreover, it functions as an anti-inflammatory agent
by inhibiting factors that promote inflammation. Respiratory ailments, from
infections to chronic obstructive pulmonary disease (COPD), are often
exacerbated by oxidative stress and inflammation. By restoring antioxidant
levels, reducing oxidative stress, and curbing inflammation, NAC offers robust
defense for the lungs, promoting respiratory health and function. Within the
respiratory system, NAC helps minimize excessive mucus production, potentially
preventing harmful bacterial and viral colonization. Through these diverse
mechanisms, N-acetyl-L-cysteine supports respiratory health, bolsters immunity,
and shields against lung-related infections. [1] [2].
The body's ability to fight viral infections heavily relies
on cellular immunity. This crucial immune response is intricately governed by
the equilibrium between oxidants and antioxidants within the body. Glutathione,
a key antioxidant, plays a vital role in preserving this balance. In seniors or
individuals with weakened immune systems, reduced glutathione levels lead to
heightened reactive oxygen species in immune cells. This imbalance can hinder
immune reactions, particularly those managed by T cells. N-acetylcysteine aids
in restoring glutathione levels, thereby bolstering immune function and
promoting overall well-being. [2]
N-acetylcysteine (NAC) is key in reducing oxidative stress
by boosting the body's own glutathione levels. Glutathione acts as a vital
antioxidant, shielding skin cells from detrimental free radicals. Through
enhancing glutathione production, NAC offers significant skincare benefits and
combats aging signs by combating reactive oxygen species that could harm the
skin's structure and performance. While further studies on the specific use of
NAC for skin health are required, its ability to decrease oxidative stress
suggests its potential as a skin health aid.
Our Formulation
The Unived NAC supplement contains 600mg of
N-acetyl-l-cysteine.
Mode of action:
Direct and Indirect antioxidant actions: NAC repletes
glutathione reserves by providing cysteine, which is a building block of
glutathione production. NAC by itself also binds to the toxic metabolites and
scavenges free radicals [3]. Glutathione regulates intracellular and
extracellular oxidative metabolism and inflammatory process and influence many
cellular regulatory functions [1].
Anti-inflammatory action: NAC suppresses inflammatory
factors such as NF-kB, TNF-a, IL-1, and IL-6. [1]
Mucolytic action: NAC breaks the disulphide bridges of the
high molecular weight glycoproteins in the mucus, resulting in thinning of
mucous. [1]
References:
1. Tenório, Micaely Cristina dos Santos, et al.
"N-acetylcysteine (NAC): impacts on human health." Antioxidants 10.6
(2021): 967.
2. Shi, Zhongcheng, and Carlos A. Puyo.
"N-acetylcysteine to combat COVID-19: an evidence review."
Therapeutics and clinical risk management (2020): 1047-1055.
3. Ershad, Muhammed, Abdullah Naji, and David Vearrier.
"N acetylcysteine." (2019).
