As athletes, we are exposed to continuous, repetitive
action, which results in repetitive stress on our joints, muscles, and tendons.
DOMS
Delayed onset muscle soreness (DOMS) is a familiar
experience for elite and novice athletes. Symptoms can range from muscle
tenderness to severely debilitating pain. DOMS is most prevalent at the
beginning of the sporting season when athletes are returning to training
following a period of reduced activity. DOMS is also common when athletes are
first introduced to certain types of activities regardless of the time of the
year. DOMS can affect athletic
performance by causing a reduction in joint range of motion, shock attenuation,
and peak torque. Alterations in muscle sequencing and recruitment patterns may
also occur, causing unaccustomed stress to be placed on muscle ligaments and
tendons. These compensatory mechanisms may increase the risk of further injury
if a premature return to sport is attempted [1].
Injuries
Foot and ankle injuries are extremely common among athletes
and other physically active individuals. Sprains, fractures, and bursitis are
other joint-related troubles typically faced by athletes. Prolonged exposure to
physical stressors, such as endurance-, strength-, sports training, and
occupational tasks can lead to suppression of immune functions and skeletal
muscle damage that triggers the inflammatory response. A Swedish study
indicates that elite male athletes who participate in high-contact sports such
as football, soccer, and rugby have a higher risk of developing knee and hip
osteoarthritis than men who exercise little or not at all [2], [3], [4].
Overreaching
Failure of the immune system to properly regulate these
responses, as a consequence of excessive training load or sub-optimal recovery,
may suppress immune functions, compromise athletic performance and increase the
risks of respiratory infections. This phenomenon is known as overreaching when
the effects are more transient, lasting days or weeks, and can progress to an
over-trained state when the malaise lasts for months [5].
Our Formulation
The differentiators that make COLOX™ a pertinent formulation
are the standardization of the ingredients, the quantum of each ingredient used
in the formulation, and its synergistic effect lending long-term and definitive
benefits to exercise-induced inflammation and injury rehab.
COLOX™ is beneficial for athletes as it accelerates and
supports your body’s natural healing and repair mechanism for injured,
inflamed, or strained joints. It reduces pain and inflammation in your joints,
with its dual action blocking COX-2 and 5-LOX, making it superior to NSAIDs and
other supplements.
Mode of action:
Boswellia serrata and Curcuma longa
- Unived’s COLOX™ is very distinct from NSAIDs (Non-Steroidal
Anti-Inflammatory Drugs). NSAIDs blocks either COX-1 or COX-2 pathways and
address only the production of prostaglandins, leaving the 5-LOX pathways open
for the synthesis of leukotrienes. Furthermore, NSAIDs have no supportive
mechanism other than the temporary suppression of pain and inflammation. COLOX™
exerts a dual action in the inflammatory path by blocking both COX-2 and 5-LOX,
enzymes that are responsible for the synthesis of prostaglandins and
leukotrienes, respectively. Both prostaglandins and leukotrienes are formed
when arachidonic acid is released and they play a key role in generating an
inflammatory response in the body. - Boswellia serrata (BS) prevents the degradation of articular
cartilage and reduced the degradation of glycosaminoglycans [5] [6]. - BS blocks the overproduction of cytokinetic activity in
damaged tissues while enhancing the blood flow to your joints. This eases stiff
joints and increases joint mobility. [7] - Curcuma longa inhibits pro-inflammatory arachidonic acid and
neutrophil function during inflammatory states. [8] - Curcumin increases and prolongs the action of the body’s
natural anti-inflammatory adrenal hormone, cortisol, and also improves
circulation, thereby flushing toxins out of small joints where cellular wastes
and inflammatory compounds are frequently trapped. [9]
Vitamin D3
- Unived’s COLOX™ derives its Vitamin D3 from lichen
extracts-the only pure plant-based and vegan source of D3. Vitamin D3 is
imperative for bone health, immune function, and inflammatory modulation and it
may even be necessary for optimal muscle function and performance
References:
1. Cheung, Karoline, Patria A. Hume, and Linda Maxwell.
"Delayed onset muscle soreness." Sports medicine 33.2 (2003):
145-164.
2. Dr. Sheldon Martin, ‘Athletes and Joint Pain: Is it
Something you have to live with?, April 2013, Orthoarizona,
www.orthopedicarizona.com.
3. Linda Thrasybule, ‘Elite Athletes at a Greater Risk of
Arthritis,’ Reuters (Health), NY, 16 Dec 2011, www.reuters.com
4. Goh, Jorming, Chin Leong Lim, and Katsuhiko Suzuki.
"Effects of endurance-, strength-, and concurrent training on cytokines
and inflammation." Concurrent aerobic and strength training. Springer,
Cham, 2019. 125-138.
5. Blain, Emma J., Ahmed Y. Ali, and Victor C. Duance.
"Boswellia frereana (frankincense) suppresses cytokine‐induced matrix
metalloproteinase expression and production of pro‐inflammatory molecules in
articular cartilage." Phytotherapy Research 24.6 (2010): 905-912.
6. Siddiqui, M. Z. "Boswellia serrata, a potential
antiinflammatory agent: an overview." Indian journal of pharmaceutical
sciences 73.3 (2011): 255.
7. Dr. David Jockers, ‘The Super Herb Boswellia – De-inflame
and heal’, October 2011, NaturalNew.com
8. Curcuma longa (Turmeric),’Monograph, Alternate Medicine
Review, 2001, Volume 6 supplement, pg. S62-S66.
9. Arthritis, NHS Choices, www.nhs.uk
