Vitamin D also known as the "sunshine vitamin," is
produced in the skin upon sun exposure. Vitamin D is also obtained through the
dietary consumption of foods such as fish, eggs, mushrooms, milk, fortified
foods, etc. Vitamin D is required to maintain serum calcium homeostasis and,
for bone metabolism [2].
Vitamin D deficiency is a global health issue that afflicts
about 1 billion people worldwide, while 50% of the population has vitamin D
insufficiency. Vitamin D deficiency may be related to populations who have
limited sun exposure due to geographical location, higher skin melanin content.
80% of adults in India are Vitamin D deficient. 96% of the elderly population
in India is Vitamin D deficient [1].
Inadequate exposure to sunlight is one of the major causes
of vitamin D insufficiency or deficiency. Vitamin D deficiency can also result
from several other causes like decreased dietary intake and or absorption,
decreased endogenous synthesis, and increased catabolic metabolism.
Sufficient vitamin D is required for optimal health. It is a
versatile vitamin with multiple action. Several studies have shown positive and
potential effects of Vitamin D3 on several bone diseases, muscle weakness, more
than a dozen types of internal cancers, multiple sclerosis, and type 1 diabetes
mellitus.
Our Formulation
Unived Basics Vegan D3 is 100% RDA Vitamin D3 sourced from
plant-based lichens a unique plant species. Basic Vegan D3 provides 600 I.U
Vitamin D3.
Mode of Action:
Vitamin D exerts its mechanism of action by binding to the
vitamin D receptor, a hormone receptor present at the nucleus inside the
cell. Vitamin D receptors are present in
the small intestine, colon, T and B lymphocytes, mononuclear cells, brain, and
skin. Thus it elucidates a wide range of action
It stimulates intestinal calcium and phosphorus absorption
[2].
May help increase muscle strength by preserving muscle
fibres, which in turn helps to prevent falls [4].
Vitamin D metabolites act on multiple domains of
cardiovascular function including those related to inflammation, and thrombosis
[3].
It stimulates nitric oxide (NO) production protects against
oxidative stress and prevents endothelial apoptosis [3].
Vitamin D and its analogs consistently suppress
pro-inflammatory cytokines and increase anti-inflammatory cytokines [3].
Vitamin D also plays a role in regulating immune function.
It induces B cell proliferation and the secretion of immunoglobulins E and M,
leading to the formation of memory B cells [3].
References:
1. Sizar O, Khare S, Goyal A, et al. Vitamin D Deficiency.
[Updated 2022 Jul 27]. In: StatPearls [Internet]. Treasure Island (FL):
StatPearls Publishing; 2022 Jan-. Available from:
https://www.ncbi.nlm.nih.gov/books/NBK532266/
2. Chauhan K, Shahrokhi M, Huecker MR. Vitamin D. [Updated
2022 Sep 9]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls
Publishing; 2022 Jan-. Available from:
https://www.ncbi.nlm.nih.gov/books/NBK441912/
3. Wang, Hanmin, et al. "Vitamin D and chronic
diseases." Aging and disease 8.3 (2017): 346.
4. Zhang, Ran, and Declan P. Naughton. "Vitamin D in
health and disease: current perspectives." Nutrition journal 9.1 (2010):
1-13.
