Bacillus coagulans Unique IS-2

BIO

Found In
Sauerkraut, kimchi, and yogurt

Form
Bacillus coagulans Unique IS-2

Source
Fermented media

Probiotics are ‘live microorganisms that confer a health benefit on the host when administered in adequate amounts (1). These friendly microorganisms in the human gastrointestinal tract play an essential role in supporting and maintaining strong immune and digestive systems. A balanced microbiota is important for a healthy immune system. A number of factors can disrupt this balance, these include the usage of antibiotics, unhealthy diets, stress, frequent travel, gastrointestinal disorders, etc. Probiotic supplements help to restore microbial balance. A balanced microbiota strengthens the epithelial gut lining and restricts pathogens and harmful agents from entering the bloodstream (2).

KEY BENEFITS

  • It helps balance intestinal flora.
  • It promotes overall gut health.
  • Supports immune health.

Description

Unique IS2 (B. coagulans), earlier known as Lactobacillus sporogenes is a Lactic Acid Bacteria (LAB). It is gram positive, spore forming bacterium. It is non-pathogenic and safe for human consumption with self-affirmed GRAS. It is naturally encapsulated therefore is a tough and stable probiotic.

Bacillus coagulans or Lactobacillus sporogenes is a high-temperature tolerant strain unlike most of the other probiotic strains. Therefore it doesn’t need refrigeration and is shelf-stable.

It is a gram-positive, facultative anaerobic, non-pathogenic, spore-forming, lactic acid-producing bacteria. These probiotic bacteria are able to withstand harsh conditions, like acidic pH in the stomach, and are very effective in maintaining overall gut health (3).

Gut health

Management of Irritable Bowel Syndrome (IBS)

B. coagulans Unique IS-2 reduces abdominal pain and increases the number of complete spontaneous bowel movements. It exhibited significant improvements in abdominal discomfort, bloating, urgency, incomplete evacuation, straining, passage of gas, bowel habit satisfaction, overall assessment of IBS symptoms, and the total score (4).

Reduces the Severity of Diarrhea

B. coagulans Unique IS-2 to alleviate diarrhoeal symptoms. A clinical trial was carried out on 28 adults suffering from acute diarrhea. At the end of the study, the duration of diarrhea decreased from 35 mins to 3.5 mins per day and the frequency of diarrhea is aslo decreased from 7.96 to 0.76 times per day. Improvement in abdominal pain and consistency of stool has been observed (5).

Immune health

A study was carried out on 68 adults aged 58-67 years old to evaluate the effect of Uniue IS-2 on immune health. Natural killer (NK) cell activity was assessed. At the end of the study, NK cell activity improved significantly in individuals consuming B. coagulans Unique IS-2 group as compared to other groups. It was found that 56% of individuals in Group 3 experienced over 200% improvement in NK cell activity compared with other groups. This result shows that B. coagulans Unique IS-2 has a role in enhancing immune response (6).

The Unived difference

Probiotics can give beneficial effects when they are administered in an effective dosage. Unique IS-2 has been studied clinically for all of its claimed benefits. It is added into the formulations in an effective & researched based dosage. It can survive harsh gastric conditions and reach the intestine to deliver the claimed benefits, unlike other probiotic strains present in the market.

Evidence-Based or Bust

We use ingredients backed by a significant body of research that is growing each day.

  1. Probiotics-mixed messages.
    Mack D. R. (2005). Probiotics-mixed messages. Canadian family physician Medecin de famille canadien, 51(11), 1455–1464.
  2. Rebuilding the Gut Microbiota Ecosystem
    Gagliardi, A., Totino, V., Cacciotti, F., Iebba, V., Neroni, B., Bonfiglio, G., ... & Schippa, S. (2018). Rebuilding the gut microbiota ecosystem. International journal of environmental research and public health, 15(8), 1679.
  3. Bacillus coagulans Unique IS2 in Constipation: A Double-Blind, Placebo-Controlled Study.
    Madempudi, R. S., Neelamraju, J., Ahire, J. J., Gupta, S. K., & Shukla, V. K. (2020). Bacillus coagulans Unique IS2 in Constipation: A Double-Blind, Placebo-Controlled Study. Probiotics and antimicrobial proteins, 12(2), 335–342.
  4. Randomized clinical trial: the effect of probiotic Bacillus coagulans Unique IS2 vs. placebo on the symptoms management of irritable bowel syndrome in adults
    Madempudi, R. S. et al. (2019) ‘Randomized clinical trial: the effect of probiotic Bacillus coagulans Unique IS2 vs. placebo on the symptoms management of irritable bowel syndrome in adults’, Scientific Reports, 9(1).
  5. Efficacy of Bacillus coagulans strain Unique IS-2 in the treatment of patients with acute diarrhea
    Sudha, R. and Bhonagiri, S. (2012) ‘Efficacy of Bacillus coagulans strain Unique IS-2 in the treatment of patients with acute diarrhea’, Int. J. Probiotics Prebiotics, 7, pp. 33–37.
  6. ENHANCEMENT OF NATURAL KILLER CELL ACTIVITY IN IMMUNO-COMPROMISED ELDERLY SUBJECTS BY BACILLUS COAGULANS
    Upadhyaya, S. and Banerjee, G. (2011) ‘ENHANCEMENT OF NATURAL KILLER CELL ACTIVITY IN IMMUNO-COMPROMISED ELDERLY SUBJECTS BY BACILLUS COAGULANS’, International Journal of Probiotics and Prebiotics, 6.

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Studies on Bacillus coagulans Unique IS-2 and Counting

B. coagulans Unique IS2 has been found to improve digestive health in adults as well as children. Unique IS-2 has been established as safe and helpful in cases of diarrhea, bacterial vaginosis, and irritable bowel syndrome (IBS).