Description

Chromium Picolinate consists of trivalent chromium, an extremely safe and highly tolerable trace mineral which is present in a normal diet and is combined with picolinate acid in order to enhance gut absorption. Chromium (Cr) is a safe and highly tolerable trace element provided by dietary intake and dietary supplementation, especially chromium picolinate (2).

Glucose metabolism

Chromium picolinate - works as an auto amplification system for insulin Signaling and helps reduce fasting blood glucose levels thus aiding the enhancement of insulin sensitivity. It also helps with reducing testosterone levels. Cr is an essential element in glucose and insulin homeostasis (2).

• Previous study have reported that daily supplementation of Cr (200-1000 mcg) in form of Cr picolinate has resulted in decreased blood glucose levels (2).

• Chromium picolinate, an over-the-counter product, improved insulin sensitivity at the insulin receptor level (2, 3) and effectively reduced insulin resistant and treated hyperinsulinemia as well as hyperandrogenemia but did not significantly affect the hormonal changes, at the elevated level of intake, was devoid of adverse effects in human studies (3).

• Chromium functions as a part of an auto amplification system for insulin Signaling and promotes enhancement of insulin sensitivity (3).

• In the patients who received chromium picolinate, Fasting Blood Sugar significantly decreased after 3 months of treatment (p=0.042) (3). Cr supplementation reduced fasting insulin in subgroup of studies with>10 participants (effect size: -0.86 mIU/ml, 95% CI: -0.67, -0.17; p = 0.001) (I2= 63.7%, P= 0.06). The serum levels of fasting insulin significantly decreased leading to an increased insulin sensitivity as measured by QUICKI index (p=0.014) (3).

• After 3 months of treatment by chromium picolinate, serum levels of testosterone decreased by 0.12. In the same way, the serum levels of free testosterone decreased by 0.2 in chromium (2, 3).

• These studies are carried out on women with PCOS thus indicating that supplementation of chromium picolinate has shown beneficial effects specifically in the PCOS population.

The Unived difference

Absorption of ingredients is very important when we are considering supplementing with them. Chromium Picolinate is absorbed in a much higher rate that the other forms of chromium. Chromium Picolinate is a form of chromium which provides chromium that is bound to picolinic acid. It facilitates its absorption, so that one get maximum benefits from chromium

Evidence-Based or Bust

We use ingredients backed by a significant body of research that is growing each day.

1. Chromium
   Chromium » Linus Pauling Institute » Micronutrient Information Center
2. Chromium supplementation and polycystic ovary syndrome: A systematic review and meta-analysis
   Fazelian, S., Rouhani, M. H., Bank, S. S., & Amani, R. (2017). Chromium supplementation and polycystic ovary syndrome: A systematic review and meta-analysis. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 42, 92–96.
3. Metformin versus chromium picolinate in clomiphene citrate-resistant patients with PCOs: A double-blind randomized clinical trial
   Amooee, S., Parsanezhad, M. E., Ravanbod Shirazi, M., Alborzi, S., & Samsami, A. (2013). Metformin versus chromium picolinate in clomiphene citrate-resistant patients with PCOs: A double-blind randomized clinical trial. Iranian journal of reproductive medicine, 11(8), 611–618.