Aging: A Complex Process
Aging is a complex process that involves molecular and
cellular decline which affects tissue function over time, making you frail and
susceptible to disease and death (1). Aging is a continuous process that begins
from the fetal stage and continues throughout the entire life. Physiological
changes occur slowly over time within the body (2).
Major risk factors for aging and age-related illnesses like
osteoarthritis, cancer, type 2 diabetes, Alzheimer's, cognitive decline,
obesity, osteoporosis, metabolic syndrome, & cardiovascular (CVD) include
oxidative stress, systemic low-grade chronic inflammation, and the impairment
of hormonal, fibrinolytic, and immune status (2).
As one cannot stop aging or prevent age-related declines but
there are ways to increase the likelihood that one will live a healthy life.
Small modifications in nutrition & lifestyle can make a big difference in
promoting healthy aging. It is more important to take early steps to maintain
your health by approaching healthy aging than to deal with age-related declines
& diseases in the later stage of life.
Reaching the age of 40 is an important milestone in life
from a health perspective. It's a time when the body's overall health is at
great risk, so it's the perfect time to address problems before they get worse.
Why body needs extra support?
Environmental stressors, modern lifestyle, inflammation,
infections & several diseases & age are some of the factors which are
responsible for oxidative stress & free radical production. Increase ROS
(Reactive oxygen species) production leads to an imbalance that can cause cell
& tissue damage. Therefore, it needs to be managed as early as possible
(3).
Our Formulation
Advanced Nutrients formulation specifically targets the
nutritional needs of middle-aged adults to support their overall well-being and
promote healthy aging. This comprehensive formula not only focuses on cognition
and energy levels but also addresses the cellular and internal factors
associated with aging. By providing essential nutrients and supporting optimal
cellular function, Advance Nutrient aims to help individuals support cognitive
function, and enhance energy levels as they age. It takes into account the
specific requirements of middle-aged adults, making it a valuable addition to
their wellness routine.
Mode of Action:
Coenzyme Q10:
Coenzyme Q10 is a compound that is involved in the making of
ATP, the major energy source of the body, and drives numerous physiological
processes by transferring electrons and protons. New website
It plays a crucial role in the generation of cellular
energy, and heart muscle contraction, and acts as a free radical scavenger (6).
Coenzyme Q10 is present in higher concentrations in heart
tissues. CoQ10 is widely recognized for its protective effect on cardiovascular
health. It strengthens the heart muscles, provides energy, and acts as an
antioxidant (7).
Carorite™ (Carotenoid complex):
Carotenoids counteract oxidative stress and thus promote
healthy aging (8). It fulfills the daily carotenoid requirements of the body.
CaroRite™ is composed of a carotenoid complex, containing the ideal dosage of
Lutein, Zeaxanthin, Beta Carotene, Alpha Carotene, Lycopene, and other
carotenoids.
It supports the antioxidant system, eye health, cognitive
function, immune health & healthy aging.
Curcumin:
Curcumin, the active ingredient in Curcuma longa, has been
extensively documented for its analgesic effect against inflammation arising
from a wide range of conditions like Osteoarthritis and Rheumatoid arthritis.
It is also reported to possess, cardiac-protective and supports healthy aging
(4).
Studies have demonstrated that Curcumin switches off
inflammation at the molecular level by blocking cyclooxygenase-2 (COX-2),
promotes the synthesis of Cortisol, and thus helps to reduce inflammation (9).
Trans-Resveratrol:
It has antioxidant, anti-inflammatory, cardiovascular
protection, anticancer, antidiabetic, neuroprotection, and antiaging effects.
Resveratrol is now looked at as an effective compound for supporting healthy
aging and managing the age-related disease (10).
It activates a protein called SIRT1, which is involved in
regulating cellular processes associated with aging. However, the impact of
resveratrol on the human lifespan is still unclear and requires further
investigation (11).
It may enhance cellular repair mechanisms, improve
mitochondrial function, and promote longevity pathways. These effects may
contribute to healthy aging at the cellular level (11).
Choline:
Choline contributes to healthy aging through various
mechanisms. It supports brain health by being involved in the production of
neurotransmitters that are crucial for cognitive function and memory (12).
Choline is also important for maintaining the integrity and
function of cell membranes, which are essential for overall cellular health (12).
It plays a role in liver health by aiding in fat metabolism
and preventing the accumulation of fat in the liver (12).
Additionally, choline has anti-inflammatory and antioxidant
properties, helping to combat inflammation and oxidative stress that can
contribute to the aging process. Lastly, choline is involved in muscle function
and may help preserve muscle strength and prevent age-related muscle loss (12).
Choline is necessary for synthesis of neurotransmitters
(acetylcholine), cell-membrane structure and signaling (phospholipids),
transport of lipids (lipoproteins), and methylation (homocysteine reduction) (12).
The body can synthesize choline but the amount is not
sufficient to meet human requirements. Therefore, choline supplementation is
beneficial to maintain overall wellbeing
Taurine:
Taurine contributes to healthy aging through its antioxidant
and anti-inflammatory effects, supporting cellular health. It has beneficial
effects on cardiovascular health, including blood pressure regulation and
improved lipid profiles. Taurine also exhibits neuroprotective properties,
supporting brain health and cognitive function. It plays a role in maintaining
mitochondrial function, which is essential for cellular energy production and
overall health. Additionally, taurine supports muscle health, reduces damage
and inflammation, and may enhance physical performance, promoting healthy aging
(13).
References:
1. Carmona, J. J., & Michan, S. (2016). Biology of
healthy aging and longevity. Revista de investigacion clinica, 68(1), 7-16.
2. González-Sarrías, A., Larrosa, M., García-Conesa, M. T.,
Tomás-Barberán, F. A., & Espín, J. C. (2013). Nutraceuticals for older
people: Facts, fictions and gaps in knowledge. Maturitas, 75(4), 313-334.
3. Pizzino, G., Irrera, N., Cucinotta, M., Pallio, G.,
Mannino, F., Arcoraci, V., Squadrito, F., Altavilla, D., & Bitto, A.
(2017). Oxidative Stress: Harms and Benefits for Human Health. Oxidative
medicine and cellular longevity, 2017, 8416763.
4. Pahari, S. K., Ghosh, S., Halder, S., & Jana, M.
(2016). Role of Coenzyme Q10 in human life. Research journal of pharmacy and
technology, 9(6), 635-640.
5. Hojerová J. (2000). Koenzým Q10--význam, vlastnosti a
vyuzitie vo výzive a kozmetike [Coenzyme Q10--its importance, properties and
use in nutrition and cosmetics]. Ceska a Slovenska farmacie : casopis Ceske
farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti, 49(3),
119–123.
6. Kumar, A., Kaur, H., Devi, P., & Mohan, V. (2009).
Role of coenzyme Q10 (CoQ10) in cardiac disease, hypertension and Meniere-like
syndrome. Pharmacology & therapeutics, 124(3), 259-268.
7. Saini R. (2011). Coenzyme Q10: The essential nutrient.
Journal of pharmacy & bioallied sciences, 3(3), 466–467.
8. Tan, B. L., & Norhaizan, M. E. (2019). Carotenoids:
How effective are they to prevent age-related diseases?. Molecules, 24(9),
1801.
9. Kunnumakkara, A. B., Bordoloi, D., Padmavathi, G.,
Monisha, J., Roy, N. K., Prasad, S., & Aggarwal, B. B. (2017). Curcumin,
the golden nutraceutical: multitargeting for multiple chronic diseases. British
journal of pharmacology, 174(11), 1325–1348.
10. Effects and Mechanisms of Resveratrol on Aging and
AgeRelated Diseases Dan-Dan Zhou , 1 Min Luo , 1 Si-Yu Huang , 1 Adila Saimaiti
, 1 Ao Shang , 1 Ren-You Gan , 2,3 and Hua-Bin Li 1
11. Pyo, I. S., Yun, S., Yoon, Y. E., Choi, J. W., &
Lee, S. J. (2020). Mechanisms of Aging and the Preventive Effects of
Resveratrol on Age-Related Diseases. Molecules (Basel, Switzerland), 25(20),
4649.
12. Zeisel, S. H., & da Costa, K. A. (2009). Choline: an
essential nutrient for public health. Nutrition reviews, 67(11), 615–623.
13. Schaffer, S., & Kim, H. W. (2018). Effects and
Mechanisms of Taurine as a Therapeutic Agent. Biomolecules & therapeutics,
26(3), 225–241.
