Our body is under constant exposure to oxidative stress
caused by a lot of factors. Oxidative stress largely impacts the body at the
cellular level and they are linked to several health conditions and diseases
including diabetes, obesity, cardiovascular diseases, and neurological diseases
[3] [9]. Therefore, our body needs to constantly replenish its antioxidant
stores and reboot its antioxidant defense mechanism through proper diet, active
lifestyle, and dietary supplements.
ALA serves as a unique biological antioxidant that
neutralizes free radicals generated by oxidative stress due to its unique
sulfur-containing structure [8]. The amount of ALA produced by the body
decreases with age along with a decline in the synthesis and recycling of other
key nutrients like glutathione, and coenzyme Q10, leaving the body vulnerable
to oxidative damage [7] [6].
Supplementing ALA may be necessary to maintain adequate
levels and regenerate other antioxidants and boost the body’s overall
antioxidant capacity against numerous complications and diseases that are
associated with impaired energy utilization and increased oxidative stress,
including type 2 diabetes, neurological diseases, and cardiovascular disease.
Our Formulation
Unived’s ALA capsules are formulated with Alpha-Lipoic Acid
and supportive minerals like Zinc, Calcium, and Magnesium.
Alpha Lipoic acid exerts multiple modes of action.
- Antioxidant activity: Neutralizes and scavenges free
radicals like singlet oxygen, superoxides, peroxyl, and hydroxyl radicals,
hypochlorite, and peroxynitrite. It regenerates other antioxidants such as
glutathione, vitamin C, vitamin E, and coenzyme Q10 [11] [14]. ALA also can
chelate metals and eliminate them which can produce an antioxidant effect [10].
- Glucose metabolism and Insulin Resistance: ALA decreases
insulin resistance and increases insulin sensitivity and effective glucose
utilization [12] [13]. - Liver Protection: ALA inhibits inflammatory mediators like
Nitric oxide and TNF-α in the injured liver, thus exhibiting its
anti-inflammatory action [15]. Alleviates NAFLD progression associated with
T2DM and triglyceride accumulation in the liver [16]. - Energy production: It
plays a pivotal role in cellular metabolism by acting as a coenzyme in energy
production [17].
The addition of small amounts of magnesium results in
reinforcement of the protective effect, especially, it increases antioxidant
defense [2].
References:
2. Markiewicz-Górka, Iwona, et al. "Alleviating effect
of α-lipoic acid and magnesium on cadmium-induced inflammatory processes,
oxidative stress and bone metabolism disorders in Wistar rats."
International journal of environmental research and public health 16.22 (2019):
4483.
4. Park, Sungmi, et al. "Physiological effect and
therapeutic application of alpha lipoic acid." Current medicinal chemistry
21.32 (2014): 3636-3645.
3. García-Sánchez, Andrés, Alejandra Guillermina
Miranda-Díaz, and Ernesto Germán Cardona-Muñoz. "The role of oxidative
stress in physiopathology and pharmacological treatment with pro-and
antioxidant properties in chronic diseases." Oxidative Medicine and
Cellular Longevity 2020 (2020).
5. Du, Gang, et al. "Lipoic acid rejuvenates aged
intestinal stem cells by preventing age‐associated endosome reduction."
EMBO reports 21.8 (2020): e49583.
6. Oregon State University. "Lipoic Acid Explored As
Anti-aging Compound." ScienceDaily. ScienceDaily, 18 May 2007.
www.sciencedaily.com/releases/2007/05/070517130823.htm
7. Packer, Lester, Eric H. Witt, and Hans Jürgen Tritschler.
"Alpha-lipoic acid as a biological antioxidant." Free radical biology
and medicine 19.2 (1995): 227-250.
8. Data, Product. "Alpha-lipoic acid."
Arzneimittelforschung 45 (1995): 872-874.
9. Pizzino G, Irrera N, Cucinotta M, Pallio G, Mannino F,
Arcoraci V, Squadrito F, Altavilla D, Bitto A. Oxidative Stress: Harms and
Benefits for Human Health. Oxid Med Cell Longev. 2017;2017:8416763. doi:
10.1155/2017/8416763. Epub 2017 Jul 27. PMID: 28819546; PMCID: PMC5,551541.
10. El Barky AR, Hussein SA and Mohamed TM. The Potent
Antioxidant Alpha Lipoic Acid. J Plant Chem and Ecophysiol. 2017; 2(1): 1016.
11. Gorąca, Anna, et al. "Lipoic acid–biological
activity and therapeutic potential." Pharmacological Reports 63.4 (2011):
849-858.
12. Lee, Woo Je, et al. "α-Lipoic acid increases
insulin sensitivity by activating AMPK in skeletal muscle." Biochemical
and biophysical research communications 332.3 (2005): 885-891.
13. Evans, Joseph L., and Ira D. Goldfine. "α-Lipoic
acid: a multifunctional antioxidant that improves insulin sensitivity in
patients with type 2 diabetes." Diabetes technology & therapeutics 2.3
(2000): 401-413.
14. Moini, Hadi, Lester Packer, and Nils-Erik L. Saris.
"Antioxidant and prooxidant activities of α-lipoic acid and dihydrolipoic
acid." Toxicology and applied pharmacology 182.1 (2002): 84-90.
15. https://clinicaltrials.gov/ct2/show/NCT04475276#wrapper
16. Ko, Chih‐Yuan, et al. "Alpha‐lipoic acid alleviates
NAFLD and triglyceridthe e accumulation in liver via modulating hepatic NLRP3
inflammasome activation pathway in type 2 diabetic rats." Food science
& nutrition 9.5 (2021): 2733-2742.
17. Krämer, Klaus, and Lester Packer. "R-α-lipoic
acid." Nutraceuticals in health and disease prevention (2001): 141-174.
