Trans-Resveratrol

What is Resveratrol? 

Resveratrol is a natural compound that belongs to a class of
plant chemicals called polyphenols. It is found in a variety of plants,
including grapes (especially red grapes), berries, peanuts, and certain herbs
like Japanese knotweed (3).

Resveratrol gained attention due to its presence in red wine
and its potential health benefits. It is known for its antioxidant properties,
meaning it helps protect cells from damage caused by harmful free radicals. It
is also recognized for its anti-inflammatory effects (4).

Resveratrol is an activator of SIRT1, a sirtuin family of
proteins, and therefore hypothesized to be beneficial in diseases associated
with abnormal metabolic control, inflammation, and cell cycle defects (5). Therefore,
it is now been looked at as a healthy aging compound.

Benefits:

1. Antioxidant and anti-inflammatory effects: Resveratrol
acts as an antioxidant, helping to protect cells from damage caused by free
radicals. It also has anti-inflammatory properties, which may help reduce
inflammation in the body (6).

2. Cardiovascular health: Resveratrol has been studied for
its potential cardiovascular benefits. It may help improve blood flow, reduce
LDL (bad) cholesterol levels, and reduce the formation of blood clots, thereby
reducing the risk of heart disease (7).

3. Brain health: Some studies suggest that resveratrol may
have neuroprotective properties and could potentially benefit brain health. It
has been linked to improvements in memory and cognitive function and may help
protect against age-related cognitive decline and neurodegenerative diseases
such as Alzheimer's disease (8).

4. Anti-cancer properties: In laboratory studies,
Resveratrol has been shown to have anti-cancer effects. It may help inhibit
cancer cell growth, prevent tumor formation, and induce apoptosis (cell death)
in cancer cells. However, more research is needed to determine its efficacy in
human cancer treatment (9).

5. Longevity: Resveratrol has been associated with increased
lifespan in certain animal studies. It activates a protein called SIRT1, which
is involved in regulating cellular processes associated with aging. However,
the impact of resveratrol on the human lifespan is still unclear and requires
further investigation (10).

Our Formulation

Resveratrol is a powerful antioxidant found in some plants.
Its antioxidant properties help to minimize cell damage caused by free
radicals. Unived’s Resveratrol contains 500mg of Trans-resveratrol which is a
bioactive and better absorbable form of resveratrol.

Research on resveratrol has explored its potential benefits
for various health conditions, including cardiovascular diseases,
neurodegenerative disorders, cancer, and metabolic conditions like obesity and
diabetes. However, it's important to note that while some studies have shown
promising results, the overall effects of resveratrol on human health are still
being investigated, and more research is needed to fully understand its
potential benefits and optimal dosage (4, 5).

References:

1. Effects and Mechanisms of Resveratrol on Aging and
AgeRelated Diseases Dan-Dan Zhou , 1 Min Luo , 1 Si-Yu Huang , 1 Adila Saimaiti
, 1 Ao Shang , 1 Ren-You Gan , 2,3 and Hua-Bin Li 1

2. Zhou, D. D., Luo, M., Huang, S. Y., Saimaiti, A., Shang,
A., Gan, R. Y., & Li, H. B. (2021). Effects and Mechanisms of Resveratrol
on Aging and Age-Related Diseases. Oxidative medicine and cellular longevity,
2021, 9932218.

3. Ramírez-Garza, S. L., Laveriano-Santos, E. P.,
Marhuenda-Muñoz, M., Storniolo, C. E., Tresserra-Rimbau, A., Vallverdú-Queralt,
A., & Lamuela-Raventós, R. M. (2018). Health Effects of Resveratrol:
Results from Human Intervention Trials. Nutrients, 10(12), 1892.

4. Khattar, S., Khan, S. A., Zaidi, S. A. A.,
Darvishikolour, M., Farooq, U., Naseef, P. P., Kurunian, M. S., et al. (2022).
Resveratrol from Dietary Supplement to a Drug Candidate: An Assessment of
Potential. Pharmaceuticals, 15(8), 957. MDPI AG.

5. Berman, A. Y., Motechin, R. A., Wiesenfeld, M. Y., &
Holz, M. K. (2017). The therapeutic potential of resveratrol: a review of
clinical trials. NPJ precision oncology, 1, 35.

6. Meng, T., Xiao, D., Muhammed, A., Deng, J., Chen, L.,
& He, J. (2021). Anti-Inflammatory Action and Mechanisms of Resveratrol.
Molecules (Basel, Switzerland), 26(1), 229.

7. Gligorijević, N., Stanić-Vučinić, D., Radomirović, M.,
Stojadinović, M., Khulal, U., Nedić, O., & Ćirković Veličković, T. (2021).
Role of Resveratrol in Prevention and Control of Cardiovascular Disorders and
Cardiovascular Complications Related to COVID-19 Disease: Mode of Action and
Approaches Explored to Increase Its Bioavailability. Molecules (Basel,
Switzerland), 26(10), 2834.

8. Cicero, A. F. G., Ruscica, M., & Banach, M. (2019).
Resveratrol and cognitive decline: a clinician perspective. Archives of medical
science : AMS, 15(4), 936–943.

9. Ko, J. H., Sethi, G., Um, J. Y., Shanmugam, M. K.,
Arfuso, F., Kumar, A. P., Bishayee, A., & Ahn, K. S. (2017). The Role of
Resveratrol in Cancer Therapy. International journal of molecular sciences,
18(12), 2589.

10. Pyo, I. S., Yun, S., Yoon, Y. E., Choi, J. W., &
Lee, S. J. (2020). Mechanisms of Aging and the Preventive Effects of
Resveratrol on Age-Related Diseases. Molecules (Basel, Switzerland), 25(20),
4649.